There are plenty of ways to play audio files with Python. It really depends on your application, but the easiest way, by far, is to use the bindings for VLC to control VLC with Python, and play your files. With VLC, you don't need to worry about codecs and file support. It also doesn't require too many complicated methods, and/or objects. So, for simple audio playback, VLC is best.
Some of the products that appear on this site are from companies from which QuinStreet receives compensation. This compensation may impact how and where products appear on this site including, for example, the order in which they appear. QuinStreet does not include all companies or all types of products available in the marketplace.