In the world of mail servers, MailScanner is one of the best open source software for virus scanning and spam detection. MailScanner relies on pre-installed anti-virus and anti-spam software to check incoming and outgoing emails for malicious content or patterns of spamming. This makes sure that the mail server does not participate in the distribution of malware and unsolicited spam emails. It also helps preventing the mail server IP from becoming blacklisted, keeping the mail server records clean. This tutorial will focus on setting up MailScanner along with Clam Antivirus and SpamAssassin in a CentOS system. The procedure should work on RHEL as well.